Prevalence of human T-lymphotropic virus type 1 and 2 (HTLV-1/-2) infection in pregnant women in Brazil: a systematic review and meta-analysis

Prevalence of human T-lymphotropic virus type 1 and 2 (HTLV-1/-2) infection in pregnant women in Brazil: a systematic review and meta-analysis

Human T-lymphotropic virus sort 1 (HTLV-1) an infection could trigger critical illness, whereas pathogenicity of HTLV-2 is much less sure. There are not any screening or surveillance packages for HTLV-1/-2 an infection in Brazil. By performing this systematic evaluation, we aimed to estimate the prevalence of HTLV-1/-2 infections in pregnant ladies in Brazil.
This evaluation included cohort and cross-sectional research that assessed the presence of both HTLV-1/-2 an infection in pregnant ladies in Brazil. We searched BVS/LILACS, Cochrane Library/CENTRAL, EMBASE, PubMed/MEDLINE, Scopus, Net of Science and grey literature from inception to August 2020. We recognized 246 information in complete. Twenty-six of these have been included within the qualitative synthesis, whereas 17 of them have been included within the meta-analysis.
The prevalence of HTLV-1 in Brazilian pregnant ladies, as recognized by a constructive screening check and a subsequent constructive confirmatory check, was 0.32% (95% CI 0.19-1.54), whereas of HTLV-2 was 0.04% (95% CI 0.02-0.08). Subgroup evaluation by area confirmed the very best prevalence within the Northeast area (0.60%; 95% CI 0.37-0.97) for HTLV-1 and within the South area (0.16%; 95% CI 0.02-1.10) for HTLV-2. The prevalence of HTLV-1 is way larger than HTLV-2 an infection in pregnant Brazilian ladies with vital variations between areas. The prevalence of each HTLV-1/-2 are larger within the Northeast in comparison with Middle-West area.

Strongyloides stercoralis and HTLV-1 coinfection in CD34+ twine blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval development

Viral and parasitic coinfections are recognized to result in each enhanced illness development and altered illness states. HTLV-1 and Strongyloides stercoralis are co-endemic all through a lot of their worldwide ranges leading to a major incidence of coinfection. Independently, HTLV-1 induces a Th1 response and S. stercoralis an infection induces a Th2 response.
Nevertheless, coinfection with the 2 pathogens has been related to the event of S. stercoralis hyperinfection and an alteration of the Th1/Th2 steadiness. On this examine, a mannequin of HTLV-1 and S. stercoralis coinfection in CD34+ umbilical twine blood hematopoietic stem cell engrafted humanized mice was established. An elevated stage of mortality was noticed within the HTLV-1 and coinfected animals when in comparison with the S. stercoralis contaminated group.
The mortality was not correlated with proviral masses or complete viral RNA. Evaluation of cytokine profiles confirmed a definite shift in the direction of Th1 responses in HTLV-1 contaminated animals, a shift in the direction of Th2 cytokines in S. stercoralis contaminated animals and elevated TNF-α responses in coinfected animals. HTLV-1 contaminated and coinfection teams confirmed a major, but non-clonal growth of the CD4+CD25+ T-cell inhabitants.
Numbers of worms within the coinfection group didn’t differ from these of the S. stercoralis contaminated group and no autoinfective larvae have been discovered. Nevertheless, infective larvae recovered from the coinfection group confirmed an enhancement in development, as was seen in mice with S. stercoralis hyperinfection brought on by remedy with steroids.
Humanized mice coinfected with S. stercoralis and HTLV-1 reveal options related to human an infection with these pathogens and supply a singular alternative to check the interplay between these two infections in vivo within the context of human immune cells.

Pathogenesis of HTLV-1 an infection and development biomarkers: An outline

An infection by human T-cell lymphotropic virus sort 1 (HTLV-1) happens in lymphocytes, which journey all through the physique, thus affecting a number of goal organs and inflicting various medical outcomes, significantly in populations which can be underserved and would not have entry to healthcare.
Nevertheless, the mechanism of pathogenesis shouldn’t be but absolutely understood. The TAX and HTLV-1 fundamental leucine zipper issue (HBZ) proteins keep viral persistence and have an effect on pathogenesis via cell proliferation and immune and inflammatory responses that accompany every medical manifestation.
TAX expression results in inhibition of transcription error management, OX40 overexpression, and cell proliferation in grownup T-cell leukemia (ATL). OX40 ranges are elevated within the central nervous system (CNS), and the expression of TAX within the CNS causes neuronal injury and lack of immune reactivity amongst sufferers with HTLV-1-associated myelopathy (HAM).
HBZ reduces viral replication and suppresses the immune response. Its cell compartmentalization has been related to the pathogenesis of HAM (cytoplasmic localization) and ATL (nuclear localization). TAX and HBZ appear to behave antagonistically in immune responses, affecting the pathogenesis of HTLV-1 an infection.
The development from HTLV-1 an infection to illness is a consequence of HTLV-1 replication in CD4+ T and CD8+ T lymphocytes and the imbalance between proinflammatory and anti inflammatory cytokines. The compartmentalization of HBZ means that this protein could also be a further device for assessing immune and inflammatory responses, along with these already acknowledged as potential biomarkers related to development from an infection to illness (together with human leukocyte antigen (HLA), killer immunoglobulin-like receptors (KIR), interleukin (IL)-6, IL-10, IL-28, Fas, Fas ligand, interferon (IFN)-γ, tumor necrosis issue (TNF)-α, and mannose-binding lectin).

Molecular Epidemiology of HIV-1 and HTLV-1\/2 Amongst Feminine Intercourse Employees in 4 Cities within the State of Para, Northern Brazil

Feminine intercourse employees (FSWs) characterize a key inhabitants for the acquisition of sexually transmitted infections (STI) on account of their social vulnerability and the dangers related to their occupation. This examine was performed to explain the sociodemographic traits and sexual habits amongst FSWs in cities in northern Brazil, to find out the prevalence of human immunodeficiency virus 1 (HIV-1) and human T-cell lymphotropic virus (HTLV-1\/2) infections and to determine the circulating subtypes of those brokers on this key inhabitants.
A cross-sectional examine utilizing the Time Location Sampling (TLS) methodology was performed amongst 339 FSWs in cities within the state of Pará from 2005 to 2006. Serological and molecular exams have been carried out to determine infections and viral subtypes, and bivariate and multivariate analyses have been performed to determine danger elements.

Prevalence of human T-lymphotropic virus type 1 and 2 (HTLV-1/-2) infection in pregnant women in Brazil: a systematic review and meta-analysis

Most FSWs have been younger, single, much less educated and had at the least one little one. The prevalence of antibodies in opposition to HIV-1 and HTLV-1 was 2.three and 1.7%, respectively. HIV-1 subtypes B (87.5%) and F1 (12.5%) have been recognized amongst FSWs, as have been Cosmopolitan subtype (1a) and Transcontinental subgroup (A).
Unprotected intercourse and illicit drug use have been related to HIV-1 and HTLV-1 infections utilizing bivariate and multivariate analyses, and age ≥27 years was related solely with HIV. The vital data highlighted right here clearly signifies that the shortage of actions to regulate and stop pathogens in FSWs and the shortage of methods for well being promotion in key populations can additional irritate the epidemiological situation of viral infections in distant areas with low human improvement indices.

Recombinant HIV HTLV-1 gp46 mosaic Protein, Untagged, E.coli-100ug

QP12355-100ug 100ug
EUR 218

Recombinant HIV HTLV-1 gp46 mosaic Protein, Untagged, E.coli-1mg

QP12355-1mg 1mg
EUR 1261

Recombinant HIV HTLV-1 gp46 mosaic Protein, Untagged, E.coli-500ug

QP12355-500ug 500ug
EUR 663

HTLV-1 gp46 recombinant protein

00701-V-01mg 0,1 mg
EUR 267.5
  • Category: Antigens, HTLV, Ag
Description: HTLV-1 gp46 recombinant protein

HTLV-1 gp46 recombinant protein

00701-V-1000ug 1000 ug
EUR 1282.5
  • Category: Antigens, HTLV, Ag
Description: HTLV-1 gp46 recombinant protein

Recombinant (E.Coli) HTLV-1 gp46

RP-575 100 ug
EUR 286

HTLV I gp46 Protein

abx060599-100ug 100 ug
EUR 676
  • Shipped within 5-10 working days.

Recombinant HTLV-1 Mosaic

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Recombinant HTLV-1 Mosaic

7-07772 500µg Ask for price

Recombinant HTLV-1 Mosaic

7-07773 1000µg Ask for price

HTLV-1 Mosaic Protein

20-abx260286
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Recombinant HTLV-1 Mosaic Protein

VAng-Lsx0310-inquire inquire Ask for price
Description: HTLV type 1 Mosaic Protein, recombinant protein from E. coli.

HTLV Mosaic protein [GST]

DAG1572 100 µg
EUR 645

HTLV-1 virus mosaic recombinant antigen

00205-V-01mg 0,1 mg
EUR 267.5
  • Category: Antigens, HTLV, Ag
Description: HTLV-1 virus mosaic recombinant antigen a.a. 374-400/190-207.

HTLV-1 virus mosaic recombinant antigen

00205-V-1000ug 1000 ug
EUR 1282.5
  • Category: Antigens, HTLV, Ag
Description: HTLV-1 virus mosaic recombinant antigen a.a. 374-400/190-207.

HTLV Glycoprotein 46 Mosaic protein

DAG1571 100 µg
EUR 645

Recombinant HTLV Mosaic Protein [GST]

VAng-Lsx0304-inquire inquire Ask for price
Description: Recombinant HTLV protein fused with GST at N-terminus was expressed in E. coli and purified by proprietary chromatographic technique.

Recombinant (E.Coli, GST tag) HTLV-1 Mosaic

RP-578 100 ug
EUR 286

Recombinant HTLV gp 46 Mosaic Protein

VAng-Lsx0303-inquire inquire Ask for price
Description: Recombinant HTLV gp46 protein containing the gp46 immunodominant regions, 162-214 amino acids and 242-257 amino acids was expressed in E. coli and purified by proprietary chromatographic technique.

Anti-HTLV Type I gp46 Clone 65/6C2.2.34 (1 mg)

0801094 1 mg
EUR 1689.04
  • What is the product classification?
  • Anti-HTLV Type I gp46 Clone 65/6C2.2.34 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

Anti-HTLV Type I gp46 Clone 68/4.11.21 (1 mg)

0801118 1 mg
EUR 1689.04
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  • Anti-HTLV Type I gp46 Clone 68/4.11.21 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

Anti-HTLV Type II gp46 Clone 73/4.9.8 (1 mg)

0801119 1 mg
EUR 1689.04
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  • Anti-HTLV Type II gp46 Clone 73/4.9.8 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

Anti-HTLV Type I gp46 Clone 67/5.5.13.1 (1 mg)

0801127 1 mg
EUR 1689.04
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  • Anti-HTLV Type I gp46 Clone 67/5.5.13.1 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

Recombinant HIV HTLV-1 mosaic Protein, Untagged, E.coli-100ug

QP12356-100ug 100ug
EUR 218

Recombinant HIV HTLV-1 mosaic Protein, Untagged, E.coli-1mg

QP12356-1mg 1mg
EUR 1261

Recombinant HIV HTLV-1 mosaic Protein, Untagged, E.coli-500ug

QP12356-500ug 500ug
EUR 663

Anti-HTLV Type I gp46 Clone 67/5.5.13.1 (100 µg)

0801084 100 µg
EUR 284
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  • Anti-HTLV Type I gp46 Clone 67/5.5.13.1 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

Anti-HTLV Type I gp46 Clone 68/4.11.21 (100 µg)

0801085 100 µg
EUR 284
  • What is the product classification?
  • Anti-HTLV Type I gp46 Clone 68/4.11.21 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

Anti-HTLV Type II gp46 Clone 73/4.9.8 (100 µg)

0801086 100 µg
EUR 284
  • What is the product classification?
  • Anti-HTLV Type II gp46 Clone 73/4.9.8 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

Anti-HTLV Type I gp46 Clone 65/6C2.2.34 (100 µg)

0802004 100 µg
EUR 284
  • What is the product classification?
  • Anti-HTLV Type I gp46 Clone 65/6C2.2.34 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

HTLV1 gp46 protein

30-041001 100 ug
EUR 457
Description: Purified recombinant HTLV1 gp46 protein

HTLV1 gp46 protein

30-042001F 1 mg
EUR 349
Description: Purified recombinant HTLV1 protein (gp46)

HTLV1 gp46 protein

30-043001F 100 ug
EUR 642
Description: Purified recombinant HTLV1 gp46 protein

Recombinant HTLV-1 Envelope

7-07753 100µg Ask for price

Recombinant HTLV-1 Envelope

7-07754 500µg Ask for price

Recombinant HTLV-1 Envelope

7-07755 1000µg Ask for price

Recombinant HTLV-1 p24

7-07759 100µg Ask for price

Recombinant HTLV-1 p24

7-07760 500µg Ask for price

Recombinant HTLV-1 p24

7-07761 1000µg Ask for price

Recombinant HTLV-1 gp21

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Recombinant HTLV-1 gp21

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Recombinant HTLV-1 gp21

7-07767 1000µg Ask for price

HTLV-1 TAX Antibody

20-abx137064
  • EUR 356.00
  • EUR 523.00
  • 0.5 mg
  • 1 mg
  • Shipped within 5-10 working days.

HTLV-1 Envelope Protein

20-abx260142
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

HTLV-1 p24 Protein

20-abx260271
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

HTLV-1 gp21 Protein

20-abx260284
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

HTLV 1 ELISA Kit

VArk-Lsx012 1 KIT Ask for price
Description: Used for analyzing the presence of the human T-Cell lymphotropic viruses.

Recombinant HTLV-1 Protein

VAng-Lsx0308-inquire inquire Ask for price
Description: HTLV type 1, recombinant protein from E. coli.

Recombinant HTLV-1 p24 Core

7-07756 100µg Ask for price

Recombinant HTLV-1 p24 Core

7-07757 500µg Ask for price

Recombinant HTLV-1 p24 Core

7-07758 1000µg Ask for price

HTLV-1 gp21 recombinant protein

00700-V-01mg 0,1 mg
EUR 267.5
  • Category: Antigens, HTLV, Ag
Description: HTLV-1 gp21 recombinant protein

HTLV-1 gp21 recombinant protein

00700-V-1000ug 1000 ug
EUR 1282.5
  • Category: Antigens, HTLV, Ag
Description: HTLV-1 gp21 recombinant protein

Tax8, HTLV - 1 (12 - 19)

5-02002 4 x 5mg Ask for price

Tax9, HTLV - 1 (11 - 19)

5-02003 4 x 5mg Ask for price

HTLV type 1 Glycoprotein 46

DAG-P2817 100 µg
EUR 724

HTLV-1 p24 Core Protein

20-abx260143
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Human HTLV-1 ELISA Kit

EHH0319 96Tests
EUR 521

Bovine HTLV-1 ELISA Kit

EBH0319 96Tests
EUR 521

Canine HTLV-1 ELISA Kit

ECH0319 96Tests
EUR 521

Anserine HTLV-1 ELISA Kit

EAH0319 96Tests
EUR 521

Goat HTLV-1 ELISA Kit

EGTH0319 96Tests
EUR 521

HTLV-1 Tax (11-19)

H-6096.0001 1.0mg
EUR 115
Description: Sum Formula: C56H79N9O12; CAS# [141677-18-1] net

HTLV-1 Tax (11-19)

H-6096.0005 5.0mg
EUR 368
Description: Sum Formula: C56H79N9O12; CAS# [141677-18-1] net

Rat HTLV-1 ELISA Kit

ERH0319 96Tests
EUR 521

Rabbit HTLV-1 ELISA Kit

ERTH0319 96Tests
EUR 521

Mouse HTLV-1 ELISA Kit

EMH0319 96Tests
EUR 521

Porcine HTLV-1 ELISA Kit

EPH0319 96Tests
EUR 521

Recombinant (E.Coli) HTLV-1 Envelope

RP-539 100 ug
EUR 286

Recombinant (E.Coli) HTLV-1 gp21

RP-574 100 ug
EUR 286

HTLV 1/2 ELISA Kit

VArk-Lsx011 1 KIT Ask for price
Description: Used for analyzing the presence of the human T-Cell lymphotropic viruses.

Recombinant HTLV-1 E Protein

VAng-Lsx0321-inquire inquire Ask for price
Description: HTLV type 1 Envelope, recombinant protein from E. coli.

Tax9, HTLV 1 (11 19) Peptide

20-abx266138
  • EUR 411.00
  • EUR 662.00
  • EUR 314.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

Guinea Pig HTLV-1 ELISA Kit

EGH0319 96Tests
EUR 521

Recombinant (E.Coli) HTLV-1 p24 Core

RP-540 100 ug
EUR 286

Recombinant HTLV-1 P24 Core Protein

VAng-Lsx0313-100g 100 µg
EUR 813
Description: HTLV type 1 P24 Core, recombinant protein from E. coli.

Recombinant HTLV-1 P24 Core Protein

VAng-Lsx0313-1mg 1 mg
EUR 3420
Description: HTLV type 1 P24 Core, recombinant protein from E. coli.

Recombinant HTLV-1 P24 Protein [His]

VAng-Lsx0314-1mgEcoli 1 mg (E. coli)
EUR 939
Description: HTLV-1 P24 Protein [His], recombinant protein from E. coli.

Recombinant HTLV-1 gp 46 Protein

VAng-Lsx0319-100g 100 µg
EUR 1844
Description: HTLV type 1 Glycoprotein 46, recombinant protein from E. coli.

Recombinant HTLV-1 E 701 Protein

VAng-Lsx0322-50g 50 µg
EUR 1754
Description: HTLV type 1 Envelope 701, recombinant protein from E. coli.

Recombinant HTLV-1 gag p19 Protein

VAng-Lsx7388-100g 100 µg
EUR 1828
Description: HTLV type 1 gag p19, recombinant protein from yeast.

Cytomegalo Virus Mosaic

PR27123 500 ug
EUR 833

Recombinant HIV-1 gp120 nef Mosaic

7-07657 100µg Ask for price

Recombinant HIV-1 gp120 nef Mosaic

7-07658 500µg Ask for price

Recombinant HIV-1 gp120 nef Mosaic

7-07659 1000µg Ask for price

HIV-1 gp120 nef Mosaic Protein

20-abx260272
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Recombinant HTLV-I+II

7-07762 5µg Ask for price

Recombinant HTLV-I+II

7-07763 20µg Ask for price

Recombinant HTLV-I+II

7-07764 1mg Ask for price

HTLV-I Env. Protein

abx060597-1mg 1 mg
EUR 1344
  • Shipped within 5-10 working days.

HTLV I gp21 Protein

abx060598-100ug 100 ug
EUR 676
  • Shipped within 5-10 working days.

HTLV I p24 Protein

abx060600-1mg 1 mg
EUR 1483
  • Shipped within 5-10 working days.

Recombinant HTLV P24 Protein

VAng-Lsx0305-inquire inquire Ask for price
Description: HTLV P24, recombinant protein from E. coli.

Recombinant HTLV-2 Protein

VAng-Lsx0309-inquire inquire Ask for price
Description: HTLV type 2, recombinant protein from E. coli.

Tax8, HTLV - 1 (12 - 19) (AA: Leu-Phe-Gly-Tyr-Pro-Val-Tyr-Val) (MW: 957.15)

SP-86611-1 1 mg
EUR 164

Recombinant Malaria Cs Mosaic

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Neglecting these info could also be inflicting the unfold of those two viruses and their respective subtypes within the normal inhabitants of northern Brazil.

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