Rapid and quantitative detection of SARS-CoV-2 IgG antibody in serum using optofluidic point-of-care testing fluorescence biosensor

The COVID-19 pandemic brings unprecedented disaster for public well being and economics on this planet. Detecting particular antibodies to SARS-CoV-2 is a strong complement for the prognosis of COVID-19 and is necessary for epidemiological research and vaccine validations. Herein, a fast and quantitative detection technique of anti-SARS-CoV-2 IgG antibody was constructed based mostly on the…

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Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles

Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles

The unfold of coronavirus illness 2019 (COVID-19) all through the world has resulted in anxious healthcare burdens and international well being crises. Creating an efficient measure to guard individuals from an infection is an pressing want. The blockage of interplay between angiotensin-converting enzyme 2 (ACE2) and S protein is taken into account an important goal…

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An overview of sequencing technology platforms applied to HTLV-1 studies: a systematic review

An overview of sequencing technology platforms applied to HTLV-1 studies: a systematic review

Human T-lymphotropic virus kind 1 (HTLV-1) was the primary human retrovirus described. The viral components concerned within the totally different scientific manifestations of contaminated people are nonetheless unknown, and on this sense, sequencing applied sciences can help viral genome research, contributing to a greater understanding of an infection consequence. At present, a number of sequencing…

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Specificity of two HIV screening tests detecting simultaneously HIV-1 p24 antigen and antibodies to HIV-1 and -2.

Specificity of two HIV screening tests detecting simultaneously HIV-1 p24 antigen and antibodies to HIV-1 and -2.

This research geared toward assessing the specificity of the Elecsys® HIV combi PT compared to the ARCHITECT® HIV Ag/Ab Combo. With each of those assays, 3997 unselected sera from sufferers of a tertiary well being care centre in Basel, Switzerland, had been screened for HIV. Reactive sera had been reanalysed on the VIDAS® HIV Duo…

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Detection of IgG3 antibodies specific to the human immunodeficiency virus type 1 (HIV-1) p24 protein as marker for recently acquired infection.

Decreasing the danger of human immunodeficiency virus sort 1 (HIV-1) transmission continues to be a public well being precedence. The event of efficient management methods depends on the quantification of the results of prophylactic and therapeutic measures in illness incidence. Though a number of assays can be utilized to estimate HIV incidence, these estimates are…

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In silico homology modelling and prediction of novel epitopic peptides from P24 protein of Haemonchus contortus.

In silico homology modelling and prediction of novel epitopic peptides from P24 protein of Haemonchus contortus.

Haemonchus contortus (HC) causes Haemonchosis in sheep and goats, with excessive mortality and morbidity because of lack of efficient vaccine and rising resistance to anthelmintic medication. The current research was geared toward creating the 3D mannequin of HCP24 protein and to establish the candidate epitopic peptides for efficient humoral and cell-mediated immune-response. The HCP24 protein…

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Lipid Binding Controls Dimerization of the Coat Protein p24 Transmembrane Helix.

Lipid Binding Controls Dimerization of the Coat Protein p24 Transmembrane Helix.

Coat protein (COP) I and COP II complexes are concerned within the transport of proteins between the endoplasmic reticulum and the Golgi equipment in eukaryotic cells. The formation of COP I/II complexes at membrane surfaces is an early step in vesicle formation and is mastered by p24, a kind I transmembrane protein. Oligomerization of p24…

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Determination of antibodies to human immunodeficiency virus type 1&2&O and P24 – antigen in pregnant women in port harcourt Nigeria.

The necessity for a remedy towards HIV an infection and a necessity to enhance HIV screening amongst low danger inhabitants reminiscent of pregnant ladies have been a difficulty because the emergence of HIV. Due to this fact, a hospital-based cross-sectional research was adopted to find out the prevalence of antibodies to HIV-1\/2/O and P24 antigen…

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Characterization and Genome Analysis of a Novel Marine Alteromonas Phage P24

Characterization and Genome Analysis of a Novel Marine Alteromonas Phage P24

Though Alteromonas is ubiquitous within the marine surroundings, little or no is understood about Alteromonas phages, with solely ten, so far, being remoted and reported on. On this research, a novel double-stranded DNA phage, Alteromonas phage P24, which infects Alteromonas macleodii, was remoted from the coastal waters off Qingdao. Alteromonas phage P24 has a siphoviral…

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p24 family proteins are involved in transport to the plasma membrane of GPI-anchored proteins in plants

p24 family proteins are involved in transport to the plasma membrane of GPI-anchored proteins in plants

p24 proteins are a household of type-I membrane proteins which cycle between the endoplasmic reticulum (ER) and the Golgi equipment by way of Coat Protein I (COPI)- and COPII-coated vesicles. They’ve been proposed to operate as cargo receptors, however the id of putative cargos in crops continues to be elusive. We beforehand generated an Arabidopsis…

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