Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles

The coronavirus illness 2019 (COVID-19) pandemic, brought on by extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is threatening individuals’s lives and impacting their well being. It’s nonetheless unclear whether or not individuals engaged in bodily exercise are at an elevated threat of SARS-CoV-2 an infection and extreme types of COVID-19. To be able to present knowledge to assist reply this query, we, subsequently, investigated the consequences of endurance coaching on the degrees of host proteins concerned in SARS-CoV-2 an infection in mice.

Eight-week-old C57BL/6J mice had been subjected to treadmill operating (17-25 m/min, 60-90 min, 5 classes/week, Eight weeks). After the intervention, the degrees of angiotensin-converting enzyme 2 (ACE2; host receptor for SARS-CoV-2), transmembrane protease serine 2 (TMPRSS2; host protease priming fusion of SARS-CoV-2 to host cell membranes), FURIN (host protease that promotes binding of SARS-CoV-2 to host receptors), and Neuropilin-1 (host coreceptor for SARS-CoV-2) had been measured in 10 organs that SARS-CoV-2 can infect (larynx, trachea, lung, coronary heart, jejunum, ileum, colon, liver, kidney, and testis).

Six organs (coronary heart, lung, jejunum, liver, trachea, and ileum) confirmed adjustments within the ranges of at the very least one of many proteins. Endurance coaching elevated ACE2 ranges in coronary heart (+66.4%), lung (+37.1%), jejunum (+24.7%) and liver (+27.4%), and FURIN in liver (+17.9%) tissue. In distinction, endurance coaching decreased Neuropilin-1 ranges in liver (-39.7%), trachea (-41.2%), and ileum (-39.7%), and TMPRSS2 in lung (-11.3%). Taken collectively, endurance coaching altered the degrees of host proteins concerned in SARS-CoV-2 cell entry in an organ-dependent method.

Coronavirus illness 2019 (COVID-19) following an infection by extreme acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has precipitated a world pandemic that’s nonetheless having critical results worldwide. This virus, which targets the lungs particularly, may injury different tissues. Angiotensin changing enzyme 2 (ACE-2) performs a key position in viral entry into host cells.

The presence of ACE-2 in varied tissues might allow viral an infection. Research of COVID-19 usually make use of postmortem tissues. Though this data supplies varied helpful outcomes, it is usually essential to conduct in vitro research to grasp optimum remedy approaches. As a result of the virus might present species-specific variations, in vitro applied sciences utilizing human cells are notably necessary.

Organoid applied sciences, three-dimensional constructions that may be obtained from human cells, are taking part in more and more necessary roles in research of SARS-CoV-2. This expertise provides a big benefit by way of mimicking in vivo tissue constructions and testing antiviral compounds. On this mini-review, we summarize research of SARS-CoV-2 utilizing each histopathological and organoid expertise approaches.

The worldwide pandemic outbreak attributable to extreme acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has created unprecedented challenges for public well being companies. Lombardy, area of the Northern Italy, has been the primary space within the Western world whose organs and tissues procurement applications have needed to face the virus pandemic emergency.

We retrospectively collected and analyzed knowledge about cardiovascular tissues (CT) in 2019 and in 2020. We aimed to explain the speedy evolution of SARS-CoV-2 regulation legal guidelines for tissue donor’s choice and harvesting from February 2020 till January 2021. As anticipated the variety of CT donors in 2020 was considerably decrease than these of 2019 (66 vs. 99, p worth 0.02).

The entire variety of CT collected from donors have been 254 in 2019 and 206 in 2020 (p 0.28). Femoral arteries had been essentially the most required vascular tissues (55.5% in 2019 and 40% in 2020). Fifty-five and forty-eight pulmonary valves had been implanted in 2019 and 2020, respectively.

Seryl-tRNA Synthetase 2, Mitochondrial (SARS2) Antibody
abx033708-400ul	Abbexa	400 ul	EUR 627.6

Seryl-tRNA Synthetase 2, Mitochondrial (SARS2) Antibody
abx033708-80l	Abbexa	80 µl	EUR 343.2

Seryl-tRNA Synthetase 2, Mitochondrial (SARS2) Antibody
20-abx126510	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Seryl-tRNA Synthetase 2, Mitochondrial (SARS2) Antibody
20-abx003637	Abbexa	EUR 493.20 EUR 710.40	100 ul 200 ul

SARS2 siRNA
20-abx932471	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

SARS2 siRNA
20-abx932472	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

SARS2 Rabbit pAb
A12297-100ul	Abclonal	100 ul	EUR 369.6

SARS2 Rabbit pAb
A12297-200ul	Abclonal	200 ul	EUR 550.8

SARS2 Rabbit pAb
A12297-20ul	Abclonal	20 ul	EUR 219.6

SARS2 Rabbit pAb
A12297-50ul	Abclonal	50 ul	EUR 267.6

SARS2 cloning plasmid
CSB-CL878836HU-10ug	Cusabio	10ug	EUR 451.2
Description: A cloning plasmid for the SARS2 gene.

SARS2 ELISA KIT|Human
EF002720	Lifescience Market	96 Tests	EUR 826.8

Mouse SARS2 shRNA Plasmid
20-abx977615	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Human SARS2 shRNA Plasmid
20-abx960340	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

SARS2 Recombinant Protein (Rat)
RP227483	ABM	100 ug	Ask for price

SARS2 Recombinant Protein (Mouse)
RP170015	ABM	100 ug	Ask for price

SARS2 Recombinant Protein (Human)
RP027610	ABM	100 ug	Ask for price

Sars2 ORF Vector (Rat) (pORF)
ORF075829	ABM	1.0 ug DNA	EUR 607.2

SARS2 ORF Vector (Human) (pORF)
ORF009204	ABM	1.0 ug DNA	EUR 114

Sars2 ORF Vector (Mouse) (pORF)
ORF056673	ABM	1.0 ug DNA	EUR 607.2

Sars2 sgRNA CRISPR Lentivector set (Rat)
K6129701	ABM	3 x 1.0 ug	EUR 406.8

Sars2 sgRNA CRISPR Lentivector set (Mouse)
K3850001	ABM	3 x 1.0 ug	EUR 406.8

SARS2 sgRNA CRISPR Lentivector set (Human)
K2089901	ABM	3 x 1.0 ug	EUR 406.8

Sars2 3'UTR GFP Stable Cell Line
TU168351	ABM	1.0 ml	Ask for price

SARS2 3'UTR GFP Stable Cell Line
TU072597	ABM	1.0 ml	EUR 1672.8

Sars2 3'UTR GFP Stable Cell Line
TU269921	ABM	1.0 ml	Ask for price

SARS2 Protein Vector (Rat) (pPM-C-HA)
PV303316	ABM	500 ng	EUR 723.6

SARS2 Protein Vector (Rat) (pPB-C-His)
PV303314	ABM	500 ng	EUR 723.6

SARS2 Protein Vector (Rat) (pPB-N-His)
PV303315	ABM	500 ng	EUR 723.6

SARS2 Protein Vector (Rat) (pPM-C-His)
PV303317	ABM	500 ng	EUR 723.6

SARS2 Protein Vector (Human) (pPM-C-HA)
PV036815	ABM	500 ng	EUR 394.8

SARS2 Protein Vector (Mouse) (pPM-C-HA)
PV226692	ABM	500 ng	EUR 723.6

SARS2 Protein Vector (Human) (pPB-C-His)
PV036813	ABM	500 ng	EUR 394.8

SARS2 Protein Vector (Human) (pPB-N-His)
PV036814	ABM	500 ng	EUR 394.8

SARS2 Protein Vector (Human) (pPM-C-His)
PV036816	ABM	500 ng	EUR 394.8

SARS2 Protein Vector (Mouse) (pPB-C-His)
PV226690	ABM	500 ng	EUR 723.6

SARS2 Protein Vector (Mouse) (pPB-N-His)
PV226691	ABM	500 ng	EUR 723.6

SARS2 Protein Vector (Mouse) (pPM-C-His)
PV226693	ABM	500 ng	EUR 723.6

Sars2 3'UTR Luciferase Stable Cell Line
TU118351	ABM	1.0 ml	Ask for price

SARS2 3'UTR Luciferase Stable Cell Line
TU022597	ABM	1.0 ml	EUR 1672.8

Sars2 3'UTR Luciferase Stable Cell Line
TU219921	ABM	1.0 ml	Ask for price

Sars2 sgRNA CRISPR Lentivector (Rat) (Target 1)
K6129702	ABM	1.0 ug DNA	EUR 184.8

Sars2 sgRNA CRISPR Lentivector (Rat) (Target 2)
K6129703	ABM	1.0 ug DNA	EUR 184.8

Sars2 sgRNA CRISPR Lentivector (Rat) (Target 3)
K6129704	ABM	1.0 ug DNA	EUR 184.8

Sars2 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K3850002	ABM	1.0 ug DNA	EUR 184.8

Sars2 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K3850003	ABM	1.0 ug DNA	EUR 184.8

Sars2 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K3850004	ABM	1.0 ug DNA	EUR 184.8

SARS2 sgRNA CRISPR Lentivector (Human) (Target 1)
K2089902	ABM	1.0 ug DNA	EUR 184.8

SARS2 sgRNA CRISPR Lentivector (Human) (Target 2)
K2089903	ABM	1.0 ug DNA	EUR 184.8

SARS2 sgRNA CRISPR Lentivector (Human) (Target 3)
K2089904	ABM	1.0 ug DNA	EUR 184.8

Mouse Seryl- tRNA synthetase, mitochondrial, Sars2 ELISA KIT
ELI-41698m	Lifescience Market	96 Tests	EUR 1038

Human Seryl- tRNA synthetase, mitochondrial, SARS2 ELISA KIT
ELI-18558h	Lifescience Market	96 Tests	EUR 988.8

Bovine Seryl- tRNA synthetase, mitochondrial, SARS2 ELISA KIT
ELI-52192b	Lifescience Market	96 Tests	EUR 1113.6

Human Seryl-tRNA Synthetase 2, Mitochondrial (SARS2) ELISA Kit
abx383028-96tests	Abbexa	96 tests	EUR 1093.2

Sars2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
K6129705	ABM	3 x 1.0 ug	EUR 451.2

Sars2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K3850005	ABM	3 x 1.0 ug	EUR 451.2

SARS2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K2089905	ABM	3 x 1.0 ug	EUR 451.2

Sars2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)
K6129706	ABM	1.0 ug DNA	EUR 200.4

Sars2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)
K6129707	ABM	1.0 ug DNA	EUR 200.4

Sars2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)
K6129708	ABM	1.0 ug DNA	EUR 200.4

Sars2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K3850006	ABM	1.0 ug DNA	EUR 200.4

Sars2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K3850007	ABM	1.0 ug DNA	EUR 200.4

Sars2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K3850008	ABM	1.0 ug DNA	EUR 200.4

SARS2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K2089906	ABM	1.0 ug DNA	EUR 200.4

SARS2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
K2089907	ABM	1.0 ug DNA	EUR 200.4

SARS2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
K2089908	ABM	1.0 ug DNA	EUR 200.4

Anti-SARS2 antibody
PAab07610	Lifescience Market	100 ug	EUR 463.2

Anti-SARS2 antibody
STJ114185	St John's Laboratory	100 µl	EUR 332.4
Description: This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene.

SARS antibody
39139-100ul	SAB	100ul	EUR 302.4

SARS antibody
70R-1444	Fitzgerald	100 ug	EUR 452.4
Description: Rabbit polyclonal SARS antibody raised against the C terminal of SARS

SARS antibody
70R-1445	Fitzgerald	100 ug	EUR 452.4
Description: Rabbit polyclonal SARS antibody raised against the middle region of SARS

SARS antibody
70R-20086	Fitzgerald	50 ul	EUR 522
Description: Rabbit polyclonal SARS antibody

SARS Antibody
DF15539	Affbiotech	100ul	EUR 420

SARS Antibody
1-CSB-PA04145A0Rb	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against SARS. Recognizes SARS from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

SARS Antibody
1-CSB-PA020709GA01HU	Cusabio	EUR 716.40 EUR 399.60	150ul 50ul
Description: A polyclonal antibody against SARS. Recognizes SARS from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

SARS E2 antibody
10R-1976	Fitzgerald	100 ul	EUR 289.2
Description: Mouse monoclonal SARS E2 antibody

SARS M antibody
10R-1977	Fitzgerald	100 ul	EUR 289.2
Description: Mouse monoclonal SARS M antibody

SARS1 Antibody / Seryl-tRNA synthetase / SERS
RQ7414	NSJ Bioreagents	100ug	EUR 419

anti- SARS antibody
FNab07609	FN Test	100µg	EUR 658.5
Description: Antibody raised against SARS

SARS Antibody, HRP conjugated
1-CSB-PA04145B0Rb	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against SARS. Recognizes SARS from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

SARS-M Antibody
abx016056-100ul	Abbexa	100 ul	EUR 493.2

SARS Antibody, FITC conjugated
1-CSB-PA04145C0Rb	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against SARS. Recognizes SARS from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

SARS-E2 Antibody
abx016055-100ul	Abbexa	100 ul	EUR 493.2

SARS Antibody, Biotin conjugated
1-CSB-PA04145D0Rb	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against SARS. Recognizes SARS from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

SARS Spike Antibody
20-abx137184	Abbexa	EUR 1262.40 EUR 1846.80 EUR 2064.00	100 ug 200 ug 300 µg

SARS Spike Antibody
20-abx137200	Abbexa	EUR 1412.40 EUR 2264.40 EUR 2665.20	100 ug 200 ug 300 µg

SARS Spike Antibody
24216-100ul	SAB	100ul	EUR 468

SARS Spike Antibody
24217-100ul	SAB	100ul	EUR 468

SARS Spike Antibody
24218-100ul	SAB	100ul	EUR 468

SARS Spike Antibody
24219-100ul	SAB	100ul	EUR 468

SARS Spike Antibody
24318-100ul	SAB	100ul	EUR 468

SARS Matrix Antibody
24319-100ul	SAB	100ul	EUR 468

SARS Matrix Antibody
24320-100ul	SAB	100ul	EUR 468

SARS virus Sn Antibody
abx032683-400ul	Abbexa	400 ul	EUR 627.6

SARS virus Sn Antibody
abx032683-80l	Abbexa	80 µl	EUR 343.2

SARS virus Sm Antibody
abx032684-400ul	Abbexa	400 ul	EUR 627.6

SARS virus Sm Antibody
abx032684-80l	Abbexa	80 µl	EUR 343.2

SARS Envelope Antibody
24321-100ul	SAB	100ul	EUR 468

SARS Envelope Antibody
24322-100ul	SAB	100ul	EUR 468

SARS N Protein Antibody
abx018255-100ug	Abbexa	100 ug	EUR 460.8

SARS N Protein Antibody
abx018256-100ug	Abbexa	100 ug	EUR 460.8

PLPro Antibody (SARS-CoV)
100863	BPS Bioscience	250 µg	EUR 360
Description: Chicken polyclonal antibody recognizing the SARS-CoV Papain-like Protease (PLpro) as a 35 kDa protein. Purified from egg yolks. This antibody recognizes PLPro from both SARS-CoV-1 and SARS-CoV-2. Does not cross react with SARS-CoV 3CL protease.

SARS-CoV Spike Antibody
3219-002mg	ProSci	0.02 mg	EUR 206.18
Description: SARS-CoV Spike Antibody: A novel coronavirus has been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

SARS-CoV Spike Antibody
3219-01mg	ProSci	0.1 mg	EUR 523.7
Description: SARS-CoV Spike Antibody: A novel coronavirus has been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

SARS-CoV Spike Antibody
3221-002mg	ProSci	0.02 mg	EUR 206.18
Description: SARS-CoV Spike Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

SARS-CoV Spike Antibody
3221-01mg	ProSci	0.1 mg	EUR 523.7
Description: SARS-CoV Spike Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

SARS-CoV Spike Antibody
3223-002mg	ProSci	0.02 mg	EUR 206.18
Description: SARS Spike Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

SARS-CoV Spike Antibody
3223-01mg	ProSci	0.1 mg	EUR 523.7
Description: SARS Spike Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

SARS-CoV Spike Antibody
3225-002mg	ProSci	0.02 mg	EUR 206.18
Description: SARS-CoV Spike antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

SARS-CoV Spike Antibody
3225-01mg	ProSci	0.1 mg	EUR 523.7
Description: SARS-CoV Spike antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

SARS Conjugated Antibody
C39139	SAB	100ul	EUR 476.4

SARS Polyclonal Antibody
A71293	EpiGentek	EUR 302.50 EUR 423.50	50 ul 100 ul

SARS Polyclonal Antibody
A53977	EpiGentek	EUR 684.66 EUR 117.70 EUR 302.50 EUR 423.50	100 µg 20 ul 50 ul 100 ul

SARS-CoV Matrix Antibody
3527-002mg	ProSci	0.02 mg	EUR 206.18
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope (3). It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design (4).

SARS-CoV Matrix Antibody
3527-01mg	ProSci	0.1 mg	EUR 523.7
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope (3). It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design (4).

SARS-CoV Matrix Antibody
3529-002mg	ProSci	0.02 mg	EUR 206.18
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak (1). SARS-CoV-2 is the seventh member of the enveloped, positive-stranded RNA viruses that are able to infect humans. The SARS-CoV-2 genome, like other coronaviruses, encodes for multiple structural and nonstructural proteins. The structural proteins include spike protein (S), envelope protein (E), membrane glycoprotein (M), nucleocapsid phosphoprotein (N), and the nonstructural proteins include open reading frame 1ab (ORF1ab), ORF3a, ORF6, ORF7a, ORF8, and ORF10 (2).The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope (3). It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design (4).

SARS-CoV Matrix Antibody
3529-01mg	ProSci	0.1 mg	EUR 523.7
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak (1). SARS-CoV-2 is the seventh member of the enveloped, positive-stranded RNA viruses that are able to infect humans. The SARS-CoV-2 genome, like other coronaviruses, encodes for multiple structural and nonstructural proteins. The structural proteins include spike protein (S), envelope protein (E), membrane glycoprotein (M), nucleocapsid phosphoprotein (N), and the nonstructural proteins include open reading frame 1ab (ORF1ab), ORF3a, ORF6, ORF7a, ORF8, and ORF10 (2).The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope (3). It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design (4).

SARS-CoV-2 Antibody (ORF8)
RQ6296	NSJ Bioreagents	100 ug	EUR 390.15
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF8 encodes a viral accessory protein.

SARS-CoV-2 Antibody (NSP2)
RQ6299	NSJ Bioreagents	100 ug	EUR 390.15
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF1ab, the largest gene, contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. Production of the longer (PP1ab) or shorter protein (PP1a) depends on a -1 ribosomal frameshifting event. The proteins, based on similarity to other coronaviruses, include the papain-like proteinase protein (NSP3), 3C-like proteinase (NSP5), RNA-dependent RNA polymerase (NSP12, RdRp), helicase (NSP13, HEL), endoRNAse (NSP15), 2'-O-Ribose-Methyltransferase (NSP16) and other nonstructural proteins. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies.

SARS-CoV-2 Antibody (NSP3)
RQ6300	NSJ Bioreagents	100 ug	EUR 390.15
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined. ORF1ab, the largest gene, contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. Production of the longer (PP1ab) or shorter protein (PP1a) depends on a -1 ribosomal frameshifting event. The proteins, based on similarity to other coronaviruses, include the papain-like proteinase protein (NSP3), 3C-like proteinase (NSP5), RNA-dependent RNA polymerase (NSP12, RdRp), helicase (NSP13, HEL), endoRNAse (NSP15), 2'-O-Ribose-Methyltransferase (NSP16) and other nonstructural proteins. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies.

SARS-CoV-2 Antibody (NSP4)
RQ6301	NSJ Bioreagents	100 ug	EUR 390.15
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF1ab, the largest gene, contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. Production of the longer (PP1ab) or shorter protein (PP1a) depends on a -1 ribosomal frameshifting event. The proteins, based on similarity to other coronaviruses, include the papain-like proteinase protein (NSP3), 3C-like proteinase (NSP5), RNA-dependent RNA polymerase (NSP12, RdRp), helicase (NSP13, HEL), endoRNAse (NSP15), 2'-O-Ribose-Methyltransferase (NSP16) and other nonstructural proteins. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies.

SARS-CoV-2 Antibody (NSP7)
RQ6302	NSJ Bioreagents	100 ug	EUR 390.15
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF1ab, the largest gene, contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. Production of the longer (PP1ab) or shorter protein (PP1a) depends on a -1 ribosomal frameshifting event. The proteins, based on similarity to other coronaviruses, include the papain-like proteinase protein (NSP3), 3C-like proteinase (NSP5), RNA-dependent RNA polymerase (NSP12, RdRp), helicase (NSP13, HEL), endoRNAse (NSP15), 2'-O-Ribose-Methyltransferase (NSP16) and other nonstructural proteins. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies.

SARS-CoV-2 Antibody (NSP8)
RQ6303	NSJ Bioreagents	100 ug	EUR 390.15
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF1ab, the largest gene, contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. Production of the longer (PP1ab) or shorter protein (PP1a) depends on a -1 ribosomal frameshifting event. The proteins, based on similarity to other coronaviruses, include the papain-like proteinase protein (NSP3), 3C-like proteinase (NSP5), RNA-dependent RNA polymerase (NSP12, RdRp), helicase (NSP13, HEL), endoRNAse (NSP15), 2'-O-Ribose-Methyltransferase (NSP16) and other nonstructural proteins. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies.

SARS-CoV-2 Antibody (NSP9)
RQ6304	NSJ Bioreagents	100 ug	EUR 390.15
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF1ab, the largest gene, contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. Production of the longer (PP1ab) or shorter protein (PP1a) depends on a -1 ribosomal frameshifting event. The proteins, based on similarity to other coronaviruses, include the papain-like proteinase protein (NSP3), 3C-like proteinase (NSP5), RNA-dependent RNA polymerase (NSP12, RdRp), helicase (NSP13, HEL), endoRNAse (NSP15), 2'-O-Ribose-Methyltransferase (NSP16) and other nonstructural proteins. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies.

SARS Coronavirus antibody
10C-CR9003M1	Fitzgerald	100 ug	EUR 598.8
Description: Mouse monoclonal SARS Coronavirus antibody

ACE2 (SARS Receptor) Antibody
abx032686-400ul	Abbexa	400 ul	EUR 627.6

ACE2 (SARS Receptor) Antibody
abx032686-80l	Abbexa	80 µl	EUR 343.2

SARS-CoV-2 Antibody (ORF3a)
RQ6295	NSJ Bioreagents	100 ug	EUR 390.15
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined. ORF3a encodes a viral accessory protein. Based on its similarity to other coronavirus proteins, ORF3a protein is thought to be a protein with ion channel activity (viroporin) that activates the NLRP3 inflammasome. ORF3a may also play a role in virus replication and pathogenesis.

SARS-CoV-2 Antibody (NSP10)
RQ6305	NSJ Bioreagents	100 ug	EUR 390.15
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF1ab, the largest gene, contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. Production of the longer (PP1ab) or shorter protein (PP1a) depends on a -1 ribosomal frameshifting event. The proteins, based on similarity to other coronaviruses, include the papain-like proteinase protein (NSP3), 3C-like proteinase (NSP5), RNA-dependent RNA polymerase (NSP12, RdRp), helicase (NSP13, HEL), endoRNAse (NSP15), 2'-O-Ribose-Methyltransferase (NSP16) and other nonstructural proteins. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies.

SARS Nucleocapsid Antibody
20-abx137185	Abbexa	EUR 1262.40 EUR 1846.80 EUR 2364.00	100 ug 200 ug 300 µg

SARS Nucleocapsid Antibody
20-abx137201	Abbexa	EUR 1412.40 EUR 2264.40 EUR 2665.20	100 ug 200 ug 300 µg

SARS Nucleocapsid antibody
10R-10470	Fitzgerald	100 ug	EUR 522
Description: Mouse monoclonal SARS Nucleocapsid antibody

SARS Nucleocapsid antibody
10R-10471	Fitzgerald	100 ug	EUR 522
Description: Mouse monoclonal SARS Nucleocapsid antibody

SARS-CoV Envelope Antibody
3533-002mg	ProSci	0.02 mg	EUR 206.18
Description: SARS Envelope Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.Envelope protein is a small polypeptide that contains at least one α-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication.

SARS-CoV Envelope Antibody
3533-01mg	ProSci	0.1 mg	EUR 523.7
Description: SARS Envelope Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.Envelope protein is a small polypeptide that contains at least one α-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication.

Polyclonal SARS Matrix Antibody
APR11178G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SARS Matrix . This antibody is tested and proven to work in the following applications:

Polyclonal SARS Matrix Antibody
APG02976G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SARS Matrix . This antibody is tested and proven to work in the following applications:

SARS-CoV spike protein Antibody
abx023139-100ug	Abbexa	100 ug	EUR 1028.4

SARS-CoV spike protein Antibody
abx023143-100ug	Abbexa	100 ug	EUR 1028.4

Seryl-tRNA Synthetase, Cytoplasmic (SARS) Antibody
abx237609-100ug	Abbexa	100 ug	EUR 610.8

Seryl-tRNA Synthetase, Cytoplasmic (SARS) Antibody
20-abx110210	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Seryl-tRNA Synthetase, Cytoplasmic (SARS) Antibody
20-abx115486	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Seryl-tRNA Synthetase, Cytoplasmic (SARS) Antibody
20-abx005165	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Anti-Spike S1 Antibody (SARS-CoV-2)
100715-1	BPS Bioscience	20 µg	EUR 300
Description: Recombinant human monoclonal antibody recognizing the SARS-CoV-2 Spike RBD glycoprotein. This antibody cross-reacts with the Spike protein from the SARS-CoV virus.

Anti-Spike S1 Antibody (SARS-CoV-2)
100715-2	BPS Bioscience	100 µg	EUR 440
Description: Recombinant human monoclonal antibody recognizing the SARS-CoV-2 Spike RBD glycoprotein. This antibody cross-reacts with the Spike protein from the SARS-CoV virus.

SARS-CoV-2 (COVID-19) NSP7 Antibody
9155-002mg	ProSci	0.02 mg	EUR 229.7
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP7 plays a role in viral RNA synthesis (3,4,5). It forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, it may synthesize substantially longer products than oligonucleotide primers.

SARS-CoV-2 (COVID-19) NSP7 Antibody
9155-01mg	ProSci	0.1 mg	EUR 594.26
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP7 plays a role in viral RNA synthesis (3,4,5). It forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, it may synthesize substantially longer products than oligonucleotide primers.

SARS-CoV-2 (COVID-19) NSP8 Antibody
9159-002mg	ProSci	0.02 mg	EUR 229.7
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP8 plays a role in viral RNA synthesis (3,4,5). Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, it may synthesize substantially longer products than oligonucleotide primers (6).

SARS-CoV-2 (COVID-19) NSP8 Antibody
9159-01mg	ProSci	0.1 mg	EUR 594.26
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP8 plays a role in viral RNA synthesis (3,4,5). Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, it may synthesize substantially longer products than oligonucleotide primers (6).

SARS-CoV-2 (COVID-19) NSP9 Antibody
9161-002mg	ProSci	0.02 mg	EUR 229.7
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP9 may participate in viral replication by acting as a ssRNA-binding protein (3).

SARS-CoV-2 (COVID-19) NSP9 Antibody
9161-01mg	ProSci	0.1 mg	EUR 594.26
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP9 may participate in viral replication by acting as a ssRNA-binding protein (3).

SARS-CoV-2 (COVID-19) NSP9 Antibody
9163-002mg	ProSci	0.02 mg	EUR 229.7
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP9 may participate in viral replication by acting as a ssRNA-binding protein (3).

SARS-CoV-2 (COVID-19) NSP9 Antibody
9163-01mg	ProSci	0.1 mg	EUR 594.26
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP9 may participate in viral replication by acting as a ssRNA-binding protein (3).

SARS-CoV-2 (COVID-19) NSP8 Antibody
9167-002mg	ProSci	0.02 mg	EUR 229.7
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP8 plays a role in viral RNA synthesis (3,4,5). Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, it may synthesize substantially longer products than oligonucleotide primers (6).

SARS-CoV-2 (COVID-19) NSP8 Antibody
9167-01mg	ProSci	0.1 mg	EUR 594.26
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP8 plays a role in viral RNA synthesis (3,4,5). Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, it may synthesize substantially longer products than oligonucleotide primers (6).

SARS-CoV-2 (COVID-19) NSP2 Antibody
9171-002mg	ProSci	0.02 mg	EUR 229.7
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP2 may play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses (3).

SARS-CoV-2 (COVID-19) NSP2 Antibody
9171-01mg	ProSci	0.1 mg	EUR 594.26
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP2 may play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses (3).

SARS-CoV-2 (COVID-19) NSP2 Antibody
9173-002mg	ProSci	0.02 mg	EUR 229.7
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP2 may play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses (3).

SARS-CoV-2 (COVID-19) NSP2 Antibody
9173-01mg	ProSci	0.1 mg	EUR 594.26
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP2 may play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses (3).

No variations had been discovered for the forms of CT requests between the two years. The median age of receivers of vascular tissues was 69.6 ± 14.6 years within the 2019 and 63.3 ± 14.9 years in 2020 (p < 0.01). The median age of receivers of pulmonary and aortic valves didn’t differ between the two years (9.32 ± 11.49 vs. 8.36 ± 10.66 and 48.67 ± 27.19 vs. 37.14 ± 31.97 respectively). Regardless of the dramatically discount of donors, the variety of CT collected has not decreased considerably and to this point the CT distribution charge is corresponding to these of 2019.