Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the incidence and development of ulcerative colitis. Though focusing on NLRP3 inflammasome has been thought of to be a possible remedy, the underlying mechanism by means of which pathway the intestinal irritation is modulated stays controversial. By specializing in the flavonoid lonicerin, some of…

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In silico homology modelling and prediction of novel epitopic peptides from P24 protein of Haemonchus contortus.

In silico homology modelling and prediction of novel epitopic peptides from P24 protein of Haemonchus contortus.

Haemonchus contortus (HC) causes Haemonchosis in sheep and goats, with excessive mortality and morbidity because of lack of efficient vaccine and rising resistance to anthelmintic medication. The current research was geared toward creating the 3D mannequin of HCP24 protein and to establish the candidate epitopic peptides for efficient humoral and cell-mediated immune-response. The HCP24 protein…

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