Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the incidence and development of ulcerative colitis. Though focusing on NLRP3 inflammasome has been thought of to be a possible remedy, the underlying mechanism by means of which pathway the intestinal irritation is modulated stays controversial. By specializing in the flavonoid lonicerin, some of…

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Lipid Binding Controls Dimerization of the Coat Protein p24 Transmembrane Helix.

Lipid Binding Controls Dimerization of the Coat Protein p24 Transmembrane Helix.

Coat protein (COP) I and COP II complexes are concerned within the transport of proteins between the endoplasmic reticulum and the Golgi equipment in eukaryotic cells. The formation of COP I/II complexes at membrane surfaces is an early step in vesicle formation and is mastered by p24, a kind I transmembrane protein. Oligomerization of p24…

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