Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the incidence and development of ulcerative colitis. Though focusing on NLRP3 inflammasome has been thought of to be a possible remedy, the underlying mechanism by means of which pathway the intestinal irritation is modulated stays controversial. By specializing in the flavonoid lonicerin, some of…

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NEDD4-like ubiquitin ligase 2 protein (NEDL2) in porcine spermatozoa, oocytes, and preimplantation embryos and its role in oocyte fertilization†

NEDD4-like ubiquitin ligase 2 protein (NEDL2) in porcine spermatozoa, oocytes, and preimplantation embryos and its role in oocyte fertilization†

The ubiquitin-proteasome system performs various regulatory and homeostatic roles in mammalian copy. Ubiquitin ligases are the substrate-specific mediators of ubiquitin-binding to its substrate proteins. The NEDD4-like ubiquitin ligase 2 (aliases NEDL2, HECW2) is a HECT-type ubiquitin ligase that incorporates one N-terminal HECW ubiquitin ligase area, one C-terminal HECT ubiquitin ligase area, one C2 area, and two…

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