Les récepteurs d'entrée du HTLV-1 : un ménage à trois

Les récepteurs d’entrée du HTLV-1 : un ménage à trois

The identification of the mobile receptor utilized by viruses to enter their goal cells is all the time a problem and so far entry receptors stay to be recognized for quite a lot of pathogenic human viruses. Human T-lymphotropic virus sort 1 (HTLV-1), the distinctive oncogenic retrovirus in human, was recognized within the early 1980…

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HTLV-1 Replication and Adult T Cell Leukemia Development

HTLV-1 Replication and Adult T Cell Leukemia Development

Human T-cell leukemia virus form 1 (HTLV-1) was present in 1980 as the first, and to date, the one retrovirus that causes human most cancers. Whereas HTLV-1 an an infection is normally asymptomatic, 3-5% of contaminated folks develop a T cell neoplasm usually referred to as grownup T cell leukemia/lymphoma (ATL) a few years after…

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An overview of sequencing technology platforms applied to HTLV-1 studies: a systematic review

An overview of sequencing technology platforms applied to HTLV-1 studies: a systematic review

Human T-lymphotropic virus kind 1 (HTLV-1) was the primary human retrovirus described. The viral components concerned within the totally different scientific manifestations of contaminated people are nonetheless unknown, and on this sense, sequencing applied sciences can help viral genome research, contributing to a greater understanding of an infection consequence. At present, a number of sequencing…

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Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression

Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression

Human T-lymphotropic virus kind 1 (HTLV-1) provirus expression is especially directed by Tax-responsive components (TRE) inside the lengthy terminal repeats (LTR). Mutations in TRE can cut back provirus expression and since a excessive proviral load (PVL) is a danger issue for the event of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we evaluated polymorphisms within the 5′…

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