Les récepteurs d'entrée du HTLV-1 : un ménage à trois

Les récepteurs d’entrée du HTLV-1 : un ménage à trois

The identification of the mobile receptor utilized by viruses to enter their goal cells is all the time a problem and so far entry receptors stay to be recognized for quite a lot of pathogenic human viruses. Human T-lymphotropic virus sort 1 (HTLV-1), the distinctive oncogenic retrovirus in human, was recognized within the early 1980…

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Analysis of a within-host HIV/HTLV-I co-infection model with immunity

Analysis of a within-host HIV/HTLV-I co-infection model with immunity

Human immunodeficiency virus (HIV) and human T-lymphotropic virus sort I (HTLV-I) are two retroviruses that assault the immune cells and impair their features. Each HIV and HTLV-I might be transmitted between people by means of direct contact with sure physique fluids from contaminated people. Due to this fact, an individual might be co-infected with each…

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HTLV-1 Replication and Adult T Cell Leukemia Development

HTLV-1 Replication and Adult T Cell Leukemia Development

Human T-cell leukemia virus form 1 (HTLV-1) was present in 1980 as the first, and to date, the one retrovirus that causes human most cancers. Whereas HTLV-1 an an infection is normally asymptomatic, 3-5% of contaminated folks develop a T cell neoplasm usually referred to as grownup T cell leukemia/lymphoma (ATL) a few years after…

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Prevalence of human T-lymphotropic virus type 1 and 2 (HTLV-1/-2) infection in pregnant women in Brazil: a systematic review and meta-analysis

Prevalence of human T-lymphotropic virus type 1 and 2 (HTLV-1/-2) infection in pregnant women in Brazil: a systematic review and meta-analysis

Human T-lymphotropic virus sort 1 (HTLV-1) an infection could trigger critical illness, whereas pathogenicity of HTLV-2 is much less sure. There are not any screening or surveillance packages for HTLV-1/-2 an infection in Brazil. By performing this systematic evaluation, we aimed to estimate the prevalence of HTLV-1/-2 infections in pregnant ladies in Brazil. This evaluation…

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An overview of sequencing technology platforms applied to HTLV-1 studies: a systematic review

An overview of sequencing technology platforms applied to HTLV-1 studies: a systematic review

Human T-lymphotropic virus kind 1 (HTLV-1) was the primary human retrovirus described. The viral components concerned within the totally different scientific manifestations of contaminated people are nonetheless unknown, and on this sense, sequencing applied sciences can help viral genome research, contributing to a greater understanding of an infection consequence. At present, a number of sequencing…

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Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression

Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression

Human T-lymphotropic virus kind 1 (HTLV-1) provirus expression is especially directed by Tax-responsive components (TRE) inside the lengthy terminal repeats (LTR). Mutations in TRE can cut back provirus expression and since a excessive proviral load (PVL) is a danger issue for the event of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we evaluated polymorphisms within the 5′…

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Specificity of two HIV screening tests detecting simultaneously HIV-1 p24 antigen and antibodies to HIV-1 and -2.

Specificity of two HIV screening tests detecting simultaneously HIV-1 p24 antigen and antibodies to HIV-1 and -2.

This research geared toward assessing the specificity of the Elecsys® HIV combi PT compared to the ARCHITECT® HIV Ag/Ab Combo. With each of those assays, 3997 unselected sera from sufferers of a tertiary well being care centre in Basel, Switzerland, had been screened for HIV. Reactive sera had been reanalysed on the VIDAS® HIV Duo…

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Detection of IgG3 antibodies specific to the human immunodeficiency virus type 1 (HIV-1) p24 protein as marker for recently acquired infection.

Decreasing the danger of human immunodeficiency virus sort 1 (HIV-1) transmission continues to be a public well being precedence. The event of efficient management methods depends on the quantification of the results of prophylactic and therapeutic measures in illness incidence. Though a number of assays can be utilized to estimate HIV incidence, these estimates are…

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In silico homology modelling and prediction of novel epitopic peptides from P24 protein of Haemonchus contortus.

In silico homology modelling and prediction of novel epitopic peptides from P24 protein of Haemonchus contortus.

Haemonchus contortus (HC) causes Haemonchosis in sheep and goats, with excessive mortality and morbidity because of lack of efficient vaccine and rising resistance to anthelmintic medication. The current research was geared toward creating the 3D mannequin of HCP24 protein and to establish the candidate epitopic peptides for efficient humoral and cell-mediated immune-response. The HCP24 protein…

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Lipid Binding Controls Dimerization of the Coat Protein p24 Transmembrane Helix.

Lipid Binding Controls Dimerization of the Coat Protein p24 Transmembrane Helix.

Coat protein (COP) I and COP II complexes are concerned within the transport of proteins between the endoplasmic reticulum and the Golgi equipment in eukaryotic cells. The formation of COP I/II complexes at membrane surfaces is an early step in vesicle formation and is mastered by p24, a kind I transmembrane protein. Oligomerization of p24…

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